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Estradiol Cream + Progesterone CapsulesTopical

Hormone Therapy (HRT) · Topical

Estradiol Cream + Progesterone Capsules

Estradiol cream with progesterone capsules may help selected menopausal symptoms after an individualized discussion of benefits and risks.

  • Prescribed only after a clinician review
  • Compounded formulation, not FDA approved
  • Follow-up care with your clinician

$299 · Month Supply 2mg/ml or 4mg/ml + 100mg, 150mg or 200mg

Choose a plan

Treatment details

Strength / size
2mg/ml or 4mg/ml (45ml) + 100mg, 150mg, or 200 mg (90 caps)
Plan options
HRT program (3 months)
Required labs before starting
Estradiol, Progesterone, Testosterone (free & total), SHBG, CBC, CMP, Lipid panel,TSH, FT4, FT3
Follow-up labs
  • If testosterone is prescribed, follow up is at 12 weeks: Estradiol, Testosterone (free & total), CBC.
  • At 1 year across the board, follow up: CMP, Lipids, Estradiol, Progesterone, Testosterone (free & total)

Ships to all 50 states.

  • Prescribed only after a licensed clinician reviews your health history
  • Discreet delivery to your door
  • Ongoing check-ins with your care team
Care options are subject to clinician evaluation, eligibility, and availability.

About this treatment

What is Estradiol / Progesterone?

Estradiol cream with progesterone capsules may help selected menopausal symptoms after an individualized discussion of benefits and risks. Compounded medicines are not FDA approved or reviewed for safety, effectiveness, or quality before marketing.

The science

How Estradiol / Progesterone works

Estradiol replaces estrogen activity that declines during menopause. Adequate progesterone helps protect the uterine lining in patients with a uterus using systemic estrogen.

Results depend on the formulation, route, and individual health factors. Evidence for an approved ingredient does not establish that a compounded product works the same way.

Hormone Therapy (HRT)Topical

Benefits & evidence

What to know about Estradiol / Progesterone

01

What it's used for

May reduce hot flashes and night sweats.

02

How it may help

May improve some estrogen-related symptoms.

03

What the evidence says

Appropriate progesterone helps protect the uterine lining.

Individual results vary and are not guaranteed.

Your next steps

What happens after you order

  1. 01

    Choose your plan

    Pick your treatment, plan length and state, then check out.

  2. 02

    Complete your intake

    Share your health history and goals in a secure online form.

  3. 03

    Clinician review

    A licensed clinician reviews your intake, orders any required labs and decides if treatment is right for you.

  4. 04

    Delivered to you

    If approved, your medication ships discreetly, with follow-up care along the way.

Safety information

Any risks?

Common side effects

Commonly reported effects include breast tenderness, spotting, bloating, headache, and drowsiness.

Talk to your clinician first

Discuss unexplained vaginal bleeding, hormone-sensitive cancer, liver disease, and a history of blood clots, stroke, or heart attack; avoid during pregnancy. Seek urgent care for chest pain, breathing trouble, or stroke symptoms.

About this medication

Compounded medications are prepared by a pharmacy for individual patients. They are not FDA approved and have not been reviewed by the FDA for safety or effectiveness.

When to stop

Stop and contact your care team if you have a severe reaction. For a medical emergency, call 911.

Frequently asked questions

Learn more about Estradiol / Progesterone

01How do I use this medicine?+

Use the cream and capsules exactly as prescribed. Do not skip progesterone without discussing your uterine protection plan with your clinician.

02When should I check in with my clinician?+

Follow your clinician's review schedule. Contact them sooner for persistent side effects, worsening symptoms, or concerns about your response.

03How should I store it?+

Follow the dispensing label for temperature, light protection, and discard dates. Ask your pharmacist before using medicine stored incorrectly.

04Do I need labs for Estradiol / Progesterone?+

Before starting: Estradiol, Progesterone, Testosterone (free & total), SHBG, CBC, CMP, Lipid panel,TSH, FT4, FT3. Follow-up: If testosterone is prescribed, follow up is at 12 weeks: Estradiol, Testosterone (free & total), CBC. At 1 year across the board, follow up: CMP, Lipids, Estradiol, Progesterone, Testosterone (free & total) Your clinician will tell you where and when to complete them.

05Which states can this ship to?+

It can ship to all 50 states.

06What if a clinician decides it isn't right for me?+

Treatment is only prescribed when a licensed clinician decides it is appropriate. If it isn't, your care team will explain why and talk through other options.

Hormone Therapy (HRT)

Round out your plan

Other treatments often explored alongside Estradiol / Progesterone. Each one still needs clinician approval.

Your next step

Ready when you are.

Choose your plan and a licensed clinician will take it from there.